2-Desoxy-4-epi-pulchellin

SKU: orb1297139

Description

2-Desoxy-4-epi-pulchellin is a cytotoxic small molecule active against a broad panel of human cancer cell lines (IC50 0.10-46.7 µM). It also exhibits significant antiviral activity against influenza strains (H1N1, H3N2) and antimycobacterial activity (IC50=7.6 µM), making it a compound of interest for oncology, virology, and infectious disease research.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 122872-03-1
• MW: 250.33
• Purity: 99.89% (May vary between batches)
• Formula: C₁₅H₂₂O₃
• SMILES: [H][C@]12C[C@@H](C)[C@]3([H])CC[C@H](O)[C@@]3(C)C[C@]1([H])C(=C)C(=O)O2
• Target: Anti-infection
• Solubility: DMSO:55 mg/mL (219.71 mM)

Bioactivity

• In Vitro:
  Dicarabrol (1), as well as three known sesquiterpenes (2-4), had potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7 μM, while they showed significant antiviral (H1N1 and H3N2) activities. Furthermore, compounds 1, 3 and 4 displayed significant antimycobacterial activity (IC50 3.7, 6.0, and 7.6 μM, respectively).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifection, Antiinfection, Anti-infection, 2Desoxy4epipulchellin, 2-Desoxy-4-epi-pulchellin, 2 Desoxy 4 epi pulchellin, Inhibitor, inhibit

Compound Identifiers

PubChem CID

10399864