2'-Deoxycytidine hydrochloride

SKU: orb1704752

Description

2'-Deoxycytidine hydrochloride is the salt form of a fundamental deoxyribonucleoside used in DNA synthesis research. It serves as a precursor to drugs like Gemcitabine and has demonstrated protective effects against cytarabine (araC) toxicity in murine models, supporting its utility in oncology and nucleotide metabolism studies.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 3992-42-5
• MW: 263.68
• Purity: 98.96% (May vary between batches)
• Formula: C₉H₁₄ClN₃O₄
• SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=CC(N)=N1.Cl
• Target: Endogenous Metabolite,Nucleoside Antimetabolite/Analog
• Solubility: DMSO:20 mg/mL (75.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.58 mM);H2O:30 mg/mL (113.77 mM)

Bioactivity

• In Vitro:
  Methods: Effects of 2'-Deoxycytidine hydrochloride (1 mM) on the cytotoxicity of 5FU against mouse myeloma SP2/0-Ag14 (SP2/0) cells lacking hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) and RH4 hybridoma cells possessing HGPRT under asynchronous conditions. Results: In both SP2/0 and RH4 cells, 5FU-reduced cell viability was restored by co-treatment but not pre-treatment with 2'-Deoxycytidine hydrochloride, but the effect of the former was often greater than that of the latter, suggesting that HGPRT may be involved in the interaction, although this may not be the primary mechanism.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2'Deoxycytidine hydrochloride, 2'-Deoxycytidine Hydrochloride, 2' Deoxycytidine hydrochloride, Deoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochloride

Compound Identifiers

PubChem CID

107488