2-Deoxy-2-fluoro-L-fucose

SKU: orb2893605

Description

2-Deoxy-2-fluoro-L-fucose is a potent inhibitor of GDP-fucose synthesis, blocking protein and polysaccharide fucosylation. It demonstrates anti-proliferative effects on cancer and endothelial cells in vitro, suggesting potential as an anti-angiogenic agent, and also inhibits plant root growth by disrupting pectin dimerization.

Research Area

Metabolism Research

Key Properties

• CAS Number: 70763-62-1
• MW: 166.15
• Purity: 99.87% (May vary between batches)
• Formula: C₆H₁₁FO₄
• SMILES: C[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O
• Target: Others,Transferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (19.86 mM);DMSO:80 mg/mL (481.49 mM)

Bioactivity

• In Vitro:
  Methods: 4T1 cells were treated with 2-Deoxy-2-fluoro-L-fucose (100, 250, 500 μM) and the Aleuria aurantia lectin (AAL) in the lysates was detected by Western Blot. Results: 2-Deoxy-2-fluoro-L-fucose reduced the AAL signal at all concentrations and inhibited fucosylation. Methods: 4T1 cells were treated with 2-Deoxy-2-fluoro-L-fucose (100 μM, 48 hours) and then plated for live cell migration analysis; Smad protein expression was assessed, and changes in signaling molecules that regulate migration were evaluated. Results: Cells treated with 2-Deoxy-2-fluoro-L-fucose had impaired migration and decreased phosphorylation of Smad 1/5 and Smad 2.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2 Deoxy 2 fluoro L fucose, 2Deoxy2fluoroLfucose, 2-Deoxy-2-fluoro-L-fucose

Compound Identifiers

PubChem CID

125766