(2-Chloropyridin-4-yl)MethanaMine Hydrochloride

SKU: orb1300000

Description

(2-Chloropyridin-4-yl)methanamine hydrochloride is a potent and selective inhibitor of the enzyme lysyl oxidase-like 2 (LOXL2), demonstrating an IC50 of 126 nM. This small molecule is a valuable research tool for studying LOXL2's role in fibrosis and cancer progression in both cellular and animal models.

Research Area

Neuroscience

Key Properties

• CAS Number: 916210-98-5
• MW: 179.05
• Purity: 98.00% (May vary between batches)
• Formula: C₆H₈Cl₂N₂
• SMILES: Cl.NCc1ccnc(Cl)c1
• Target: Monoamine Oxidase
• Solubility: 10% DMSO+90% Saline:5 mg/mL (27.93 mM);DMSO:60 mg/mL (335.1 mM)

Bioactivity

• Target IC50:
  LOXL2:126 nM
• In Vitro:
  (2-Chloropyridin-4-yl)methanamine hydrochloride (hLOXL2 IC50 = 126 nM), was shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B, and SSAO).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(2 Chloropyridin 4 yl)MethanaMine Hydrochloride, (2Chloropyridin4yl)MethanaMine Hydrochloride, (2-Chloropyridin-4-yl)MethanaMine Hydrochloride, LOXL2, MonoamineOxidase, Monoamine Oxidase, inhibit, MAO, Inhibitor

Compound Identifiers

PubChem CID

66570668