2-(Bromomethyl)acrylic acid

SKU: orb3210494

Description

2-(Bromomethyl) acrylic acid is an inhibitor of Bruton’s tyrosine kinase (BTK). It covalently bonds with the cysteine 481 (Cys481) residue of BTK through a nucleophilic addition-elimination reaction, effectively inhibiting downstream B-cell receptor signaling pathways. This compound can induce immunogenic cell death in BTK-expressing B-cell lymphoma cells by releasing damage-associated molecular patterns, including extracellular ATP and HMGB1. It exhibits cytotoxicity towards BTK-positive B-cell lymphoma cells while showing lower toxicity to BTK-negative cells. 2-(Bromomethyl) acrylic acid is useful for research into B-cell lymphomas.

Key Properties

• CAS Number: 72707-66-5
• MW: 164.99
• Formula: C₄H₅BrO₂
• SMILES: O=C(O)C(=C)CBr
• Target: BTK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BTK