2-Bromo-4'-hydroxyacetophenone

SKU: orb1300089

Description

2-Bromo-4'-hydroxyacetophenone (PTP Inhibitor I) is a cell-permeable, covalent inhibitor of SHP-1 and PTP1B (Ki ~42-43 μM). Its inhibition of these phosphatases makes it a useful research tool for studying insulin signaling and immune cell regulation in the contexts of diabetes, inflammation, and cancer research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2491-38-5
• MW: 215.04
• Purity: 99.07%
• Formula: C₈H₇BrO₂
• SMILES: OC1=CC=C(C=C1)C(=O)CBr
• Target: Phosphatase
• Solubility: H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.3 mM);Ethanol:20 mg/mL (93.01 mM);DMSO:60 mg/mL (279.02 mM)

Bioactivity

• Target IC50:
  PTP1B:42 μM (Ki, cell free)|SHP1:43 μM (Ki, cell free)
• Cell Research:
  Cell lines: human B cells. Concentrations: 30, 100, 300, 1000 μM. Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, alpha-Bromo-4-hydroxyacetophenone, a-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Bromide, 4-Hydroxyphenacyl bromide, 2-Bromo-4'-hydroxyacetophenone, 2Bromo4'hydroxyacetophenone, 2 Bromo 4' hydroxyacetophenone, Phosphatase, SHP-1 Inhibitor II, PTP Inhibitor I, protein tyrosine phosphatase(PTP), α-Bromo-4-hydroxyacetophenone

Compound Identifiers

PubChem CID

4964