2-Arachidonoylglycerol

SKU: orb1707757

Description

2-Arachidonoylglycerol (2-AG) is a full agonist of neuronal cannabinoid receptors. This endogenous endocannabinoid is a key research tool for studying synaptic plasticity, as it inhibits the induction of long-term potentiation at hippocampal CA3–CA1 synapses in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53847-30-6
• MW: 378.55
• Purity: 95.00% (May vary between batches)
• Formula: C₂₃H₃₈O₄
• SMILES: O(C(CO)CO)C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O
• Target: Cannabinoid Receptor,Endogenous Metabolite
• Solubility: DMSO:10 mg/mL (26.42 mM)

Bioactivity

• Target IC50:
  CB1:0.8 μM
• In Vitro:
  2-Arachidonylglycerol (2-AG), a cannabinoid ligand obtained from intestinal tissue, functions as a full agonist in activating neuronal cannabinoid receptors. It impedes the development of long-term potentiation at CA3-CA1 synapses and, by binding to cannabinoid receptors, produces effects characteristic of cannabinoid drugs.

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB1, CannabinoidReceptor, Cannabinoid Receptor, 2Arachidonoylglycerol, 2-Arachidonoylglycerol, 2 Arachidonoylglycerol, inhibit, Inhibitor, Endogenous Metabolite, EndogenousMetabolite, Human Endogenous Metabolite

Compound Identifiers

PubChem CID

5282280