2-Aminoethyl diphenylborinate

SKU: orb1302646

Description

2-Aminoethyl diphenylborinate (2-APB) is a versatile research compound primarily known as an inhibitor of IP3 receptors and TRP channels. At higher concentrations, it can also activate TRPV1-3 channels. This dual activity makes it a valuable tool for studying calcium signaling and channel physiology in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 524-95-8
• MW: 225.09
• Purity: 99.92% (May vary between batches)
• Formula: C₁₄H₁₆BNO
• SMILES: NCCOB(c1ccccc1)c1ccccc1
• Target: Calcium Channel,TRP/TRPV Channel
• Solubility: 5% DMSO+95% Saline:1.13 mg/mL (5.02 mM);DMSO:255 mg/mL (1132.88 mM);Ethanol:10 mM

Bioactivity

• Target IC50:
  IP3:42 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TRPV2, TRPV3, TRPV1, TRPVChannel, TRPChannel, TRPV Channel, TRPM8, TRPC6, TRP Channel, Transient receptor potential channels, Ca channels, Calcium Channel, CalciumChannel, Ca2+ channels, 2-Aminoethoxydiphenyl borate, 2Aminoethyl diphenylborinate, 2-Aminoethyl diphenylborinate, 2 Aminoethyl diphenylborinate, 2-APB, Inhibitor, IP3 receptor, inhibit

Compound Identifiers

PubChem CID

1598