(1S,2R)-2-PCCA

SKU: orb1962284

Description

(1S,2R)-2-PCCA is a potent and selective GPR88 agonist, exhibiting high potency with EC50 values of 3 nM in cell-free assays and 603 nM in cellular systems. This research tool is valuable for investigating GPR88 function in striatal circuitry, supporting both in vitro and in vivo studies of CNS disorders like addiction and Parkinson's disease.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• MW: 528.56
• Purity: 99.34% (May vary between batches)
• Formula: C₃₀H₃₉Cl₂N₃O
• SMILES: CC[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)CCC)C=C1)C([C@@H]3[C@H](C4=CC=CC=N4)C3)=O.Cl.Cl
• Target: GPCR
• Solubility: DMSO:55 mg/mL (104.06 mM)

Bioactivity

• Target IC50:
  GPR88 receptor:3 nM (EC50)|Gαi-coupled pathway:56 nM
• In Vitro:
  (1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay and 603 nM in cell assay. In HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct, (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(1S,2R)-2-PCCA（Iso-1609563-71-4）, 1609563-71-4-isomer, 2-PCCA, GPR88

Compound Identifiers

PubChem CID

171360099