18β-Glycyrrhetinic acid

SKU: orb1310997

Description

18β-Glycyrrhetinic acid

Research Area

Metabolism Research

Key Properties

• CAS Number: 471-53-4
• MW: 470.68
• Purity: 99.64%
• Formula: C₃₀H₄₆O₄
• SMILES: [H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)C3CC[C@@]12C)C(O)=O
• Target: Dehydrogenase,Endogenous Metabolite
• Solubility: DMSO:252.5 mg/mL (536.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.25 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Rats in Enoxolone+Triptolide (TP) group which receive low-dose Enoxolone (50 mg/kg) have significant reductions in the three serum parameters when Compare with TP rats. Rats in Enoxolone+TP group which receiv the high-dose Enoxolone (100 mg/kg) have slightly lowere the levels of three liver enzymes the reductions do not Each statistical significance Compare with TP group. Contrastingly, preadministration of low-dose Enoxolone protects animals from TP-induced hepatic lesions. O the contrary, low-dose Enoxolone (50 mg/kg) markedly suppresse the release o the four cytokines above.
• In Vitro:
  MTS assay demonstrates that 24 h treatment of Enoxolone suppresses cell proliferation In both cell lines in a dose-dependent manner. Enoxolone at 160 μM significantly decrease the percentage of viable cells to around 40. ± 0.5% in A549 and 38. ± .6% in NCI-H460 ( < .01 respectively. Whe the cells are treated with 320 μM Enoxolone, a greater inhibitory effects on cell proliferation is shown, a the percentage of viable cells is below 30% Compare with untreated controls ( < .001). Treatment with Enoxolone at 160 μM and 320 μM decrease the levels of full-length PARP and increase the levels of cleaved-PARP.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Dehydrogenase, 18beta-Glycyrrhetinic acid, 18b-Glycyrrhetinic acid, 18β Glycyrrhetinic acid, 18βGlycyrrhetinic acid, 18β-Glycyrrhetinic acid, inhibit, Enoxolone, Endogenous Metabolite, EndogenousMetabolite, Glycyrrhetin, Inhibitor

Compound Identifiers

PubChem CID

9897771