18-2-9b2

SKU: orb3033090

Description

18-2-9b2 is a dendron-like degradable ionizable lipid which facilitates mRNA delivery to splenic macrophages. 18-2-9b2 LNP encapsulating therapeutic BTB domain and CNC homologue 1 (BACH1) mRNA exhibited proficient BACH1 expression and subsequent Spic downregulation in splenic red pulp macrophages (RPM) in a Spic-GFP transgene model.

Key Properties

• MW: 2787.1
• Purity: 0.98
• Formula: C₁₅₉H₂₉₃O₃₂N₅
• SMILES: CCCCC(CC)CCC(=O)OCC(CC)(COC(=O)CCC(CC)CCCC)COC(=O)CCN(CCOCCN(CCC(=O)OCC(CC)(COC(=O)CCC(CC)CCCC)COC(=O)CCC(CC)CCCC)CCN1CCN(CCOCCN(CCC(=O)OCC(CC)(COC(=O)CCC(CC)CCCC)COC(=O)CCC(CC)CCCC)CCC(=O)OCC(CC)(COC(=O)CCC(CC)CCCC)COC(=O)CCC(CC)CCCC)CC1)CCC(=O)OCC(CC)(COC(=O)CCC(CC)CCCC)COC(=O)CCC(CC)CCCC

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only