15(S)-HpETE

SKU: orb1694176

Description

15(S)-HpETE is an arachidonic acid metabolite generated via the 15-lipoxygenase pathway, known for its anti-angiogenic properties. This bioactive lipid can modulate endothelial cell function by upregulating CD31 and selectin expression, making it a relevant tool for studying inflammation and vascular biology in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 70981-96-3
• MW: 336.47
• Formula: C₂₀H₃₂O₄
• SMILES: [C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O)(CCCCC)OO
• Target: JNK,DNA/RNA Synthesis,Drug Metabolite,Akt,Bcl-2 Family,Apoptosis
• Solubility: Ethanol:Miscible;0.1 M Na2CO3:<1 mg/mL (Insoluble or slightly soluble.);DMSO:Miscible;PBS (pH 7.2):<1 mg/mL (Insoluble or slightly soluble.);DMF:Miscible

Bioactivity

• In Vitro:
  15(S)-HpETE is involved in the regulation of a variety of cell signaling pathways and biological processes by inducing the expression of c-fos and c-jun genes and activating AP-1 transcription factor. This regulatory mechanism is important for understanding inflammatory responses, cellular stress responses, and other diseases related to lipid metabolism.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, AP-1, 15HpETE, 15(S) HpETE, 15(S)HpETE, 15S-HpETE, JNK, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

5280893