12(S)-HHT

SKU: orb2893604

Description

12(S)-HHT (12(S)-HHTrE), a fatty acid produced via the arachidonic acid metabolic pathway of cyclooxygenase (COX), is an endogenous ligand and agonist of BLT2, and the 12(S)-HHT/BLT2 axis plays a role in the maintenance of homeostatic aspects of epithelial tissues and in inflammatory responses. 12(S)-HHT inhibits the p38 MAPK/NF-κB pathway through upregulation of MKP-1, leading to reduced IL-6 synthesis in UVB-irradiated HaCaT cells.

Key Properties

• CAS Number: 54397-84-1
• MW: 280.4
• Formula: C₁₇H₂₈O₃
• SMILES: [C@@H](/C=C/C=C/C/C=C\CCCC(O)=O)(CCCCC)O
• Target: Leukotriene Receptor,Endogenous Metabolite

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Leukotriene Receptor,Endogenous Metabolite