12R-LOX-IN-1

• Catalog Number: orb1941314
• Category: Small Molecules
• Description: 12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX. It suppresses hyperproliferation and colony formation in Imiquimod-induced psoriatic keratinocytes, and reduces levels of reactive oxygen species, Ki67, IL-17A, TNF-α, and IL-6. This compound has utility in antipsoriatic research [1].
• CAS Number: 857758-13-5
• Purity: 98.00%
• MW: 237.25
• SMILES: OC=1C=CC=2N=C(C=CC2C1)C=3C=CC=CC3O
• Formula: C₁₅H₁₁NO₂
• Biological Activity: 12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX. It suppresses the hyperproliferative condition and the ability to form colonies in Imiquimod-induced psoriatic keratinocytes, as well as reducing levels of reactive oxygen species, Ki67, IL-17A, TNF-α, and IL-6. This compound has utility in antipsoriatic research [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.