12-O-Tiglyl-phorbol 13-dodecanoate

SKU: orb3211782

Description

12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a promising inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of oral APOL2 inhibitors. It exhibits no significant toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series can inhibit the expression of fibronectin, type I collagen, and α-smooth muscle actin in hepatic stellate cells. This compound can be isolated from the Euphorbia fischeriana plant and is useful for hepatic fibrosis research.

Key Properties

• CAS Number: 37394-32-4
• MW: 628.84
• Formula: C₃₇H₅₆O₈
• SMILES: O(C(CCCCCCCCCCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(/C(=C/C)/C)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others