116-9e

SKU: orb1701964

Description

This small molecule inhibitor targets the Hsp70 co-chaperone DNAJA1, demonstrating antiviral activity by suppressing SV40 replication and TAg functions. It serves as a valuable research tool for investigating viral oncology mechanisms and Hsp70-related pathways in cancer drug resistance, with utility in both in vitro and cell-based assays.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 831217-43-7
• MW: 512.6
• Purity: 99.55% (May vary between batches)
• Formula: C₃₁H₃₂N₂O₅
• SMILES: C(OCC1=CC=CC=C1)(=O)C=2C(NC(=O)N(CCCCCC(O)=O)C2C)C3=CC=C(C=C3)C4=CC=CC=C4
• Target: Virus Protease
• Solubility: DMSO:80 mg/mL (156.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.44 mM)

Bioactivity

• In Vitro:
  116-9e (MAL2-11B) inhibits Hsp70 stimulated by TAg more effectively than MAL3-101, significantly reducing virus replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain.116-9e (MAL2-11B; 15 μM; 5 days) significantly decreases BK virus in human renal cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

116 9e, 1169e, 116-9e, MAL2 11B, MAL211B, MAL-2-11B, MAL2-11B, MAL 2 11B, Virus Protease, VirusProtease

Compound Identifiers

PubChem CID

5461634