11-​Keto-​beta-​boswellic acid

SKU: orb1297519

Description

11-Keto-beta-boswellic acid is a dual-activity small molecule that activates the Nrf2 pathway and selectively inhibits 5-lipoxygenase (5-LOX). It demonstrates a dose-dependent cardioprotective effect, as evidenced by reduced serum lactate dehydrogenase levels in research models. This compound is used in studies investigating oxidative stress, inflammation, and cardiovascular protection in both cellular and animal systems.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 17019-92-0
• MW: 470.68
• Purity: 99.70% (May vary between batches)
• Formula: C₃₀H₄₆O₄
• SMILES: [H][C@@]12[C@@H](C)[C@H](C)CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@@H](O)[C@](C)(C(O)=O)[C@]3([H])CC[C@@]12C
• Target: Lipoxygenase,NF-κB,Leukotriene Receptor
• Solubility: DMSO:22.5 mg/mL (47.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.25 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3K, inhibit, Lipoxygenase, LOX, NFκB, NF-κB, NO Synthase, Nuclear factor-κB, Nuclear factor-kappaB, NF-kB, NFkB, Inhibitor, LeukotrieneReceptor, leukotriene receptor, Leukotriene Receptor, Akt, 5-LOX, 11​Keto​beta​boswellic acid, 11 ​Keto ​beta ​boswellic acid, 11-Keto-β-boswellic acid, 11-Keto-b-boswellic acid, 11-Keto-beta-boswellic acid

Compound Identifiers

PubChem CID

9847548