10074-A4

SKU: orb1297969

Description

10074-A4 is a small molecule ligand that binds the c-Myc370–409 region, forming a dynamic "ligand cloud" around its protein target. This compound is a valuable chemical probe for studying c-Myc function and protein-ligand interactions in cancer research, enabling both in vitro binding assays and cellular mechanistic studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 312631-87-1
• MW: 409.286
• Purity: 99.06% (May vary between batches)
• Formula: C₁₈H₁₄Cl₂N₂O₃S
• SMILES: OC(CN1C(=O)CSC1=O)CN1C2=C(C=C(Cl)C=C2)C2=C1C=CC(Cl)=C2
• Target: c-Myc
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.77 mM);DMSO:100 mg/mL (244.33 mM)

Bioactivity

• Target IC50:
  c-Myc:15.1 ± 2.3 μM(EC50)|c-Myc:36.3 ± 9.0 μM(Kd)
• In Vitro:
  10074-A4 showed binding affinity with c-Myc370–409 with Kd of 36.3 ± 9.0 μM and EC50 of 15.1 ± 2.3 μM.10074-A4 arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cycle, CDK4, cell, cMyc, c-Myc, CCND2, anticancer, 10074 A4, 10074A4, 10074-A4, 10074-A-4, MYC, Myc, Inhibitor, inhibit

Compound Identifiers

PubChem CID

2836204