10058-F4

SKU: orb1225110

Description

10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM; arrests AML cells at G0/G1 phase, downregulates c-Myc expression and upregulates CDK inhibitors p21 and p27; induces apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2, upregulation of Bax, release of cytoplasmic cytochrome C, and cleavage of caspase 3, 7, and 9; also induces myeloid differentiation.

Key Properties

• CAS Number: 403811-55-2
• MW: 249.3518
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₁NOS₂
• SMILES: O=C1NC(S/C1=C/C2=CC=C(CC)C=C2)=S
• Target: c-Myc
• Solubility: DMSO: ≥ 41 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

10058-F4 | 10058F4 | 10058 F4

Quick Database Links

Gene Symbol

c-Myc