10-Deacetyl-7-xylosyl paclitaxel

SKU: orb1301526

Description

10-Deacetyl-7-xylosyl paclitaxel is a semi-synthetic, water-soluble derivative of paclitaxel. It is utilized in cancer research for its enhanced pharmacological profile and has demonstrated antitumor activity in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 90332-63-1
• MW: 943.98
• Purity: 99.76%
• Formula: C₅₀H₅₇NO₁₇
• SMILES: CC(=O)O[C@@]12CO[C@@H]1C[C@H](O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
• Target: Microtubule Associated,ADC Cytotoxin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.12 mM);DMSO:25 mg/mL (26.48 mM)

Bioactivity

• In Vivo:
  10-Deacetyl-7-xylosyl paclitaxel is an active compound used in traditional Chinese medicine to treat cancer.10-Deacetyl-7-xylosyl paclitaxel through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 10-Deacetyl-7-xylosyl paclitaxel transport (16.3±6.3×10 (-6)cm/s; n=3) suggests that the drug may still be effectively absorbed in the intestinal tract.
• In Vitro:
  10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

10Deacetyl7xylosyl paclitaxel, 10-Deacetyl-7-xylosyl paclitaxel, 10-Deacetyl-7-xylosyltaxol, 10-Deacetylpaclitaxel 7-Xyloside, 10-Deacetyltaxol 7-Xyloside, 10 Deacetyl 7 xylosyl paclitaxel, 7-Xylosyl-10-deacetyltaxol, ADC Cytotoxin, ADCCytotoxin, ADC Payload, MicrotubuleAssociated, Microtubule/Tubulin, Microtubule Associated, inhibit, Inhibitor

Compound Identifiers

PubChem CID

9811678