1-Isomangostin

SKU: orb1297144

Description

1-Isomangostin is a bioactive small molecule exhibiting cytotoxic and anticomplementary properties. It is utilized in research areas such as immunology and oncology, with studies demonstrating its activity in both in vitro cell-based assays and in vivo models of inflammation and cancer.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 19275-44-6
• MW: 410.46
• Purity: 99.71% (May vary between batches)
• Formula: C₂₄H₂₆O₆
• SMILES: O=C1C=2C3=C(C(O)=CC2OC=4C1=C(CC=C(C)C)C(OC)=C(O)C4)CCC(C)(C)O3
• Target: Lipase,NF-κB

Bioactivity

• In Vitro:
  Garcimangostanol (1), 8-deoxygartanin (2), 1-Isomangostin (3), and garcinone C (4) exhibited either significant o r moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro with IC50 values from 4.0 +/- 0.3 to 23.6+/- 1.5 microM by MTT colorimetric assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p65, NF-κB, NFkB, NFκB, NF-kB, 1 Isomangostin, 1Isomangostin, 1-Isomangostin

Compound Identifiers

PubChem CID

5281641