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1-Ethynylnaphthalene

SKU: orb1220463

Description

1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1.

Images & Validation

Key Properties

CAS Number15727-65-8
MW152.19
Purity>98% (HPLC)
FormulaC12H8
SMILESC#Cc1cccc2ccccc12
TargetP450
SolubilityDMSO:125 mg/mL (821.34 mM)

Bioactivity

In Vitro
1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • 1-Ethynylnaphthalene [orb1299828]

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Protocol Information

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