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019854-B06

SKU: orb3173871

Description

019854-B06 is a potent inhibitor of Tat-mediated HIV-1 transcription, with an IC50 of 1.44 μM, and exhibits antiviral activity against HIV-1 with an EC50 of 0.83 μM. It binds to the Tat peptide (KD= 33.5 μM) but does not interact with TAR RNA. The compound neither promotes Tat degradation nor disrupts the Tat/CycT1 complex, suggesting it operates through a Tat-centered, non-degradative mechanism.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

TargetHIV Protease

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information