VU0361737

SKU: orb1300522

Description

VU0361737 (ML-128) is a selective positive allosteric modulator of mGlu4 with EC50 values of 240 nM for human and 110 nM for rat receptors. It shows weak activity at mGlu5 and mGlu8, is inactive at other mGlu subtypes, crosses the blood-brain barrier, and is used in Parkinson's disease research involving in vitro and in vivo experiments.

Research Area

Neuroscience

Key Properties

• CAS Number: 1161205-04-4
• MW: 262.69
• Purity: 99.60%
• Formula: C₁₃H₁₁ClN₂O₂
• SMILES: COc1cc(NC(=O)c2ccccn2)ccc1Cl
• Target: GluR
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (7.61 mM);DMSO:45 mg/mL (171.3 mM)

Bioactivity

• Target IC50:
  mGluR4 (rat):110 nM(EC50)|mGluR4 (human):240 nM(EC50)
• In Vivo:
  VU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1).
• In Vitro:
  VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

disease, inhibit, neuroprotective, ML128, ML-128, ML 128, Parkinson's, mGluR, mGluR4 (Human), mGluR4 (Rat ), Metabotropic glutamate receptors, Inhibitor, VU0361737, VU-0361737, VU 0361737

Compound Identifiers

PubChem CID

44191096