VU 0361737

SKU: orb1223417

Description

VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively).

Key Properties

• CAS Number: 1161205-04-4
• MW: 262.69
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₁ClN₂O₂
• SMILES: COc1c(ccc(c1)NC(=O)c1ccccn1)Cl
• Target: mGluR4 (Human)| mGluR4 (Rat )
• Solubility: DMSO : ≥ 43 mg/mL 163.69 mM

Bioactivity

• In Vivo:
  VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection (rat 10 mg/kg). Animal model: Male Sprague-Dawley rats (225-250 g). Dosage: 10 mg/kg (Pharmacokinetic Analysis). Administration: Intraperitoneal injection. Result: T1/2 (1.9 h).
• In Vitro:
  VU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. VU0361737 (1-10 μM) partially attenuates the Staurosporine (HY-15141)- and Doxorubicin (HY-15142)-evoked cell death on human neuroblastoma SH-SY5Y cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VU 0361737, VU-0361737, VU0361737

Quick Database Links

Gene Symbol

mGluR4 (Human)| mGluR4 (Rat )