VU-29

SKU: orb1305613

Description

VU-29 is a potent and selective positive allosteric modulator of the mGlu5 receptor, exhibiting an EC50 of 9 nM. Its selectivity over other mGluR subtypes makes it a valuable research tool for investigating mGlu5 function in neuropharmacology, synaptic plasticity, and related in vitro and in vivo models.

Research Area

Neuroscience

Key Properties

• CAS Number: 890764-36-0
• MW: 384.39
• Purity: 99.63%
• Formula: C₂₂H₁₆N₄O₃
• SMILES: N(C(=O)C1=CC=C(N(=O)=O)C=C1)C=2N(N=C(C2)C3=CC=CC=C3)C4=CC=CC=C4
• Target: GluR
• Solubility: DMSO:25 mg/mL (65.04 mM)

Bioactivity

• Target IC50:
  mGluR4 (human):154 nM (EC50)|mGluR2 (rat):1.5 μM (EC50)|mGluR1 (rat):557 nM (EC50)|mGluR5 (rat):224 nM (Ki)|mGluR5 (rat):9 nM (EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

allosteric, hippocampal, Inhibitor, inhibit, mGluR, Metabotropic glutamate receptors, LTD, LTP, rat, potentiator, VU29, VU-29, VU 29

Compound Identifiers

PubChem CID

11610682