VU 29

SKU: orb1219775

Description

VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).

Key Properties

• CAS Number: 890764-36-0
• MW: 384.39
• Purity: >98% (HPLC)
• Formula: C₂₂H₁₆N₄O₃
• SMILES: [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
• Target: GluR
• Solubility: In Vitro: DMSO : 50 mg/mL (130.08 mM)

Bioactivity

• In Vivo:
  VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 μM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 μM) potentiates stimulus-induced NMDA receptor-independent LTD.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GluR