Vancomycin prodrug

SKU: orb3027461

Description

Vancomycin prodrug (compound 13c) is a prodrug of Vancomycin. It exhibits antibacterial activity against Staphylococcus aureus (S. aureus) 330041, methicillin-resistant Staphylococcus aureus (MRSA) USA 300, and MRSA 3390, with minimum inhibitory concentrations (MICs) of 0.78 μM, 0.78 μM, and 1.56 μM, respectively. This prodrug can rapidly bind to the Cys-34 residue in plasma. It demonstrates therapeutic efficacy in mice infected with MRSA USA300, comparable to Vancomycin. As an albumin-binding, acid-sensitive prodrug, Vancomycin prodrug maintains Vancomycin's effectiveness against gram-positive bacterial infections while significantly reducing nephrotoxicity.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• Formula: C₈₅H₉₅Cl₂N₁₁O₂₉
• Target: Antibiotic,Autophagy,Antibacterial

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Antibiotic,Autophagy,Antibacterial