Ceftobiprole medocaril

SKU: orb1303246

Description

Ceftobiprole medocaril is a prodrug that is converted in vivo to the active cephalosporin, ceftobiprole. This broad-spectrum antibiotic demonstrates potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and is utilized in research involving both in vitro susceptibility testing and in vivo efficacy models for resistant bacterial infections.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 376653-43-9
• MW: 690.66
• Purity: 95.14%
• Formula: C₂₆H₂₆N₈O₁₁S₂
• SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\O)/C=3N=C(N)SN3)=O)C2=O)(SCC1/C=C\4/C(=O)N(CC4)[C@H]5CN(C(OCC=6OC(=O)OC6C)=O)CC5)[H]
• Target: Antibacterial

Bioactivity

• In Vivo:
  Ceftobiprole medocaril (10, 40, 160 mg/kg; single dose; sc) has T 1/2 s from 20 min to 31 min, as the dose rose from 40 mg/kg to 160 mg/kg. The AUC/dose values for the escalating single doses ranges from 0.585 to 1.33, and the C max /dose values decreases from 1.08 to 0.90 in neutropenic thigh-infected mice . The drug showed activities in the lung model similar to those in the thigh model.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

gram-negative, gram-positive, MRSA, Inhibitor, inhibit, methicillin, pathogens, Bacterial, BAL 5788, BAL5788, BAL-5788, Antibacterial, Ceftobiprole medocaril, cephalosporin, staphylococci, Prodrug, penicillin, pyrrolidinone, VRSA, vancomycin

Compound Identifiers

PubChem CID

135413544