Vadadustat

SKU: orb2281186

Description

Vadadustat is an orally active, titratable small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH). It is used in research to study anemia treatment mechanisms, demonstrating efficacy in both cellular assays and animal models of renal anemia.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 1000025-07-9
• MW: 306.7
• Purity: 99.80%
• Formula: C₁₄H₁₁ClN₂O₄
• SMILES: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
• Target: HIF/HIF Prolyl-Hydroxylase,HIF
• Solubility: DMSO:100 mg/mL (326.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.04 mM)

Bioactivity

• Target IC50:
  PH2:0.029 μM|FIH (factor inhibiting HIF):29 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

disease, chronic, anemia, AKB 6548, AKB6548, AKB-6548, inhibit, kidney, nondialysis-dependent, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF, HIF-PH, HIF/HIFProlylHydroxylase, HIFs, HIFProlylHydroxylase, Inhibitor, Hypoxia-inducible factors, Erythropoiesis-stimulating, PG1016548, PG-1016548, PG 1016548, Vadadustat

Compound Identifiers

PubChem CID

23634441