Unifiram

SKU: orb1303707

Description

Unifiram is a cognitive enhancer that potentiates hippocampal synaptic transmission (EC50=27 nM) and stimulates cortical acetylcholine release. This small molecule is used in neuroscience research to study mechanisms of learning and memory in both in vitro electrophysiology and in vivo animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 272786-64-8
• MW: 298.33
• Purity: 99.90%
• Formula: C₁₃H₁₅FN₂O₃S
• SMILES: Fc1ccc(cc1)S(=O)(=O)N1CCN2C(CCC2=O)C1
• Target: iGluR,Others
• Solubility: DMF:30 mg/mL (100.56 mM);Ethanol:1 mg/mL (3.35 mM);DMSO:30 mg/mL (100.56 mM);DMSO:PBS (pH 7.2) (1:4):0.2 mg/mL (0.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.7 mM)

Bioactivity

• In Vivo:
  Unifiram (0.1 mg kg 1 i.p.) was able to prevent amnesia induced by scopolamine (0.8 mg kg 1 i.p.) in the rat Morris watermaze test. In the rat social learning test, Unifiram (0.1 mg kg 1 i.p.) injected in adults rats reduced the duration of active exploration of the familiar partner in the second session of the test. Unifiram, similarly to piracetam, reduced the duration of hypnosis induced by pentobarbital. At the highest effective doses, the investigated compound did not impair motor coordination (rota rod test), nor modified spontaneous (Animex).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Unifiram

Compound Identifiers

PubChem CID

9861054