UK-371804

SKU: orb1304198

Description

UK-371804

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 256477-09-5
• MW: 385.83
• Purity: 95.81%
• Formula: C₁₄H₁₆ClN₅O₄S
• SMILES: CC(C)(NS(=O)(=O)c1ccc2c(Cl)cnc(NC(N)=N)c2c1)C(O)=O
• Target: Serine Protease,PAI-1
• Solubility: DMSO:8 mg/mL (20.73 mM);10% DMSO+90% Corn Oil:0.5 mg/mL (1.3 mM)

Bioactivity

• Target IC50:
  uPA:10 nM. (Ki)
• In Vivo:
  In vitro studies have shown that UK-3718046 is an inhibitor of exogenous uPA in human chronic wound fluid, displaying inhibitory capabilities with an IC50 of 0.89 μM.
• In Vitro:
  In the acute excision wound model in pigs, topical administration of UK-3718046 penetrates porcine wounds and inhibits exogenous uPA activity without adverse effects on wound-healing parameters.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, PAI1, PAI-1, Inhibitor, uPA, UK371804, UK-371804, UK 371804, SerineProtease, Serine Protease, Plasminogen activator inhibitor-1

Compound Identifiers

PubChem CID

9952109