Trolox

SKU: orb1307667

Description

Trolox

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 53188-07-1
• MW: 250.30
• Purity: >98%
• Formula: C₁₄H₁₈O₄
• SMILES: CC1=C2C(OC(C(O)=O)(C)CC2)=C(C)C(C)=C1O
• Target: Antioxidant
• Solubility: Soluble in DMSO (25 mg/ml); or ethanol (25 mg/ml); or water at alkaline pH. Do not store solutions.

Bioactivity

• Target IC50:
  HL-60 cells:0.3 μg/mL|RPMI8226 cells:> 300 μM|MCF-7 cells:> 300 μM|U-937 cells:300 μM|RAW 264.7 cells:30 μM|Melan-a cells:300 μM|MT-4 cells:200 μM|Erythrocyte:101 μM|SH-SY5Y cells:82.3 μM|HepG2 cells:> 300 μM
• In Vivo:
  METHODS: To investigate the neuroprotective effects, Trolox (50 mg/kg) was intraperitoneally injected once a day for ten days into an MPTP-induced Parkinson's disease mouse model. RESULTS: Trolox may exert neuroprotective effects on dopaminergic neurons against MPTP-induced oxidative stress, neuroinflammation, motor dysfunction and neurodegeneration.
• In Vitro:
  METHODS: Human cervical cancer cells HeLa were treated with Trolox (2.5-160 µM) for 24 h and cell viability was measured using MTT assay. RESULTS: Cell viability decreased dose-dependently, with the maximum effect observed at 160 µM Trolox. METHODS: Human skin fibroblasts were treated with Trolox (0.5 mM) for 96 h. The expression levels of target proteins were measured by Western Blot. RESULTS: Trolox increased the mitochondrial levels of Mfn2 in primary human skin fibroblasts without affecting these levels of Drp1 and hFis1.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antioxidant, Apoptosis, inhibit, Ferroptosis, Inhibitor, Reactive Oxygen Species, ReactiveOxygenSpecies, Trolox

Compound Identifiers

PubChem CID

40634