(R)-Trolox

SKU: orb1708732

Description

(R)-Trolox is a selective tyrosinase inhibitor employed in research applications. It is utilized in studies investigating melanogenesis inhibition, particularly in in vitro assays for skin depigmentation, and in exploring antioxidant mechanisms relevant to cosmetic, food, and pharmaceutical sciences.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 53101-49-8
• MW: 250.29
• Purity: 99.88%
• Formula: C₁₄H₁₈O₄
• SMILES: CC1=C2C(O[C@](C(O)=O)(C)CC2)=C(C)C(C)=C1O
• Target: Tyrosinase
• Solubility: DMSO:160 mg/mL (639.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.98 mM)

Bioactivity

• Target IC50:
  Tyrosinase:1.88 mM|Tyrosinase:0.83 mM (Ki)
• In Vivo:
  Intravenous infusion of (R)-Trolox (2.5 mg/kg) can effectively improve tubular cell transformation, brush boundary loss, vacuolation, tubular formation and tubular obstruction in ischemia-reperfusion rats, and has renal protection against I/R injury.
• In Vitro:
  (R)-Trolox is a powerful inhibitor of membrane damage that inhibits thymus cell apoptosis induced by oxidative stress.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Trolox, (R) Trolox, (R)Trolox

Compound Identifiers

PubChem CID

6541354