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TRAcP Antibody / TRAP / ACP5

TRAcP Antibody / TRAP / ACP5

Catalog Number: orb749748

DispatchUsually dispatched within 5-10 working days
$ 764.00
Catalog Numberorb749748
CategoryAntibodies
DescriptionIt recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
Species/HostMouse
ClonalityMonoclonal
Clone NumberACP5/1070
Tested applicationsIHC-P
ReactivityHuman, Mouse, Rat
IsotypeMouse IgG2b, kappa
ImmunogenRecombinant full-length human protein was used as the immunogen for the TRAcP antibody.
Dilution rangeImmunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT
PurityProtein G affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Hazard InformationThis TRAcP antibody is available for research use only.
UniProt IDP13686
StorageStore the TRAcP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the TRAcP antibody should be determined by the researcher.1. Staining of formalin/paraffin tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Expiration Date12 months from date of receipt.
  • TRAcP Antibody / TRAP / ACP5 [orb385880]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg, 20 μg
  • TRAcP Antibody / TRAP / ACP5 [orb606365]

    IHC-P

    Human, Mouse, Rat

    Rabbit

    Recombinant

    Unconjugated

    20 μg, 100 μg
  • TRAcP Antibody / TRAP / ACP5 [orb606366]

    IHC-P

    Human, Mouse, Rat

    Mouse

    Recombinant

    Unconjugated

    20 μg, 100 μg
  • TRAcP Antibody / TRAP / ACP5 [orb749749]

    IHC-P

    Human, Mouse, Rat

    Mouse

    Monoclonal

    Unconjugated

    20 μg, 100 μg
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