TMS

SKU: orb1304031

Description

TMS (2,3',4,5'-Tetramethoxystilbene) is a potent and highly selective competitive inhibitor of cytochrome P450 1B1 (CYP1B1). This small molecule is a valuable research tool for investigating CYP1B1 function in chemical carcinogenesis and estrogen metabolism, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 24144-92-1
• MW: 300.35
• Purity: 99.17% (May vary between batches)
• Formula: C₁₈H₂₀O₄
• SMILES: COc1ccc(\C=C\c2cc(OC)cc(OC)c2)c(OC)c1
• Target: Cytochromes P450
• Solubility: DMSO:50 mg/mL (166.47 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.66 mM)

Bioactivity

• Target IC50:
  CYP1A2:3.1 μM (IC50)|CYP1B1:3 nM (Ki)|CYP1B1:6 nM (IC50)|CYP1A1:300 nM (IC50)
• In Vivo:
  Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period
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• In Vitro:
  Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TMS, Inhibitor, inhibit, 2,3',4,5'-Tetramethoxystilbene, 2,3',4,5'-tetramethoxystilbene, (E)-2,3',4,5'-tetramethoxystilbene, CYPs, CYP450 1B1, Cytochrome P450

Compound Identifiers

PubChem CID

5354004