Tinidazole

SKU: orb1310193

Description

Tinidazole is a 5-nitroimidazole antiprotozoal agent. Its proposed mechanism involves metabolic conversion to reactive intermediates, such as nitro radicals, which cause cytotoxicity through sulfhydryl depletion and DNA damage. This compound is widely used in research for studying anaerobic protozoan infections in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 19387-91-8
• MW: 247.27
• Purity: 99.97%
• Formula: C₈H₁₃N₃O₄S
• SMILES: CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O
• Target: Antibiotic,Antibacterial,Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (10.11 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:60 mg/mL (242.65 mM)

Bioactivity

• In Vivo:
  Tinidazole exhibits antimicrobial activity against a broad range of bacteria, including notable anaerobic species (e.g., Bacteroides fragilis, Clostridium difficile), pathogenic protozoa (e.g., Trichomonas vaginalis, Entamoeba histolytica, Giardia duodenalis), and microaerophilic Helicobacter pylori. The compound is active against clinical isolates of 10 Prevotella bivia strains, 11 Bacteroides fragilis strains, and 40 Clostridium difficile strains. The average minimum inhibitory concentrations (MIC) for Tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL. In susceptible bacterial and protozoal cells, Tinidazole is reduced to a cytotoxic intermediate that covalently binds to DNA, causing irreversible damage. At low minimum lethal concentrations (MLC), Tinidazole can kill metronidazole-sensitive strains but is only effective against 4 out of 12 metronidazole-resistant strains. Additionally, Tinidazole inhibits all 104 T. vaginalis strains tested with an average MLC of 1014.9 μM and alters morphology, viability, and compliance of trophozoites to Giardia duodenalis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

infections, inhibit, Inhibitor, CP 12574, CP-12574, CP12574, Antibiotic, anaerobic, antimicrobial, bacteria, Bacterial, Tinidazole

Compound Identifiers

PubChem CID

5479