Secnidazole

SKU: orb1225267

Description

Secnidazole (trade names Flagentyl, Sindose, Secnil) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. Secnidazole is structurally related to the commonly used 5-nitroimidazoles metronidazole and tinidazole. (In Vitro):Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively.Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition.Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2.Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6.Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC50 value of 10 mg/mL.(In Vivo):Secnidazole (100 μL; ip.; for 5 days) has protective activity against S.marcescens pathogenesis and can diminish its pathogenesis in mice.

Key Properties

• CAS Number: 3366-95-8
• MW: 185.18
• Purity: >98% (HPLC)
• Formula: C₇H₁₁N₃O₃
• SMILES: (2RS)-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
• Target: Others
• Solubility: Ethanol: 37 mg/mL (199.8 mM); Water: 37 mg/mL (199.8 mM); DMSO: 37 mg/mL (199.8 mM)

Bioactivity

• In Vivo:
  Secnidazole (100 μL; ip. ; for 5 days) has protective activity against S. marcescens pathogenesis and can diminish its pathogenesis in mice. Animal model: Female healthy albino mice. Dosage: 100 μL. Administration: 100 μL; ip. ; for 5 days. Result: Significantly diminished the bacteria s capacity to kill mice.
• In Vitro:
  Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively. Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition. Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2.Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6.Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller-Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S. marcescens growth with a MIC50 value of 10 mg/mL. Cell Viability Assay Cell line: S. marcescens Concentration: 10 μL (the secnidazole solution was two-fold serially diluted using Mueller-Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) Incubation time: 20 h. Result: Had no inhibitory effect on S. marcescens growth at 2 mg/mL (equivalent to 1/5 MIC).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PM 185184 | RP 14539

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