Tezacaftor

SKU: orb1305866

Description

Tezacaftor (VX-661) is a CFTR corrector small molecule used in research to investigate cystic fibrosis therapies. It facilitates the cellular processing and trafficking of mutant CFTR proteins, with applications in both in vitro biochemical assays and in vivo preclinical models of CFTR dysfunction.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1152311-62-0
• MW: 520.5
• Purity: 99.94%
• Formula: C₂₆H₂₇F₃N₂O₆
• SMILES: CC(C)(CO)c1cc2cc(NC(=O)C3(CC3)c3ccc4OC(F)(F)Oc4c3)c(F)cc2n1C[C@@H](O)CO
• Target: CFTR,Autophagy
• Solubility: DMSO:245 mg/mL (470.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.61 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  DEGS:3 µM
• In Vivo:
  The F508del mutation channel can avoid degradation and be transported to the cell membrane under the action of VX-661.

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Cystic fibrosis transmembrane conductance regulator, CFTR, Autophagy, Tezacaftor, VFTR, VX661, VX-661, VX 661

Compound Identifiers

PubChem CID

46199646