A77 1726

SKU: orb1304595

Description

Teriflunomide

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 108605-62-5
• MW: 270.21
• Purity: >98%
• Formula: C₁₂H₉F₃N₂O₂
• SMILES: N#CC(C(=O)NC1=CC=C(C=C1)C(F)(F)F)=C(O)C
• Target: Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)
• Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).

Bioactivity

• In Vivo:
  Teriflunomide acts as a dihydroorotate dehydrogenase inhibitor, thereby inhibiting the de novo synthesis of pyrimidine in rapidly proliferating cells. By suppressing highly proliferative T and B lymphocytes, Teriflunomide effectively reduces the inflammatory response to self-antigens.
• In Vitro:
  In animal models of demyelinating diseases, Teriflunomide has demonstrated efficacy. For instance, in the black rat model of autoimmune encephalomyelitis, Teriflunomide has shown both preventive and therapeutic effects; similarly, in female Lewis rat models of Experimental Autoimmune Encephalomyelitis (EAE), it has been effective in ameliorating symptoms and reducing disease exacerbation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Teriflunomide

Compound Identifiers

PubChem CID

54677977