Teriflunomide

SKU: orb1304595

Description

Teriflunomide

Research Area

Metabolism Research

Key Properties

• CAS Number: 108605-62-5
• MW: 270.21
• Purity: 99.49%
• Formula: C₁₂H₉F₃N₂O₂
• SMILES: N#CC(C(=O)NC1=CC=C(C=C1)C(F)(F)F)=C(O)C
• Target: Dehydrogenase
• Solubility: DMSO:6.25 mg/mL (23.13 mM)

Bioactivity

• In Vivo:
  Teriflunomide acts as a dihydroorotate dehydrogenase inhibitor, thereby inhibitin the de novo synthesis of pyrimidine in rapidly proliferating cells. By suppressing highly Proliferative T and B lymphocytes, Teriflunomide effectively reduce the inflammatory response to self-antigens.
• In Vitro:
  In animal models of demyelinating diseases, Teriflunomide has demonstrated efficacy. For instance, in the black rat model of autoimmune encephalomyelitis, Teriflunomide has shown both preventive and therapeutic effects; similarly, in f Male Lewis rat models of Experimental Autoimmune Encephalomyelitis (EAE), it has been effective in ameliorating symptoms and reducing disease exacerbation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

HMR1726, HMR-1726, HMR 1726, Flucyamide, Dihydroorotate Dehydrogenase, Aubagio, (E/Z)-Teriflunomide, A77 1726, Teriflunomide

Compound Identifiers

PubChem CID

54677977