TCN213

SKU: orb1220128

Description

TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2BTCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions. Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope. TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible. In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity. In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents. Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist.

Key Properties

• CAS Number: 556803-08-8
• MW: 376.54
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₄N₄OS₂
• SMILES: O=C(CSc1nnc(NCc2ccccc2)s1)NCC1CCCCC1
• Target: NMDAR
• Solubility: In Vitro: DMSO : 250 mg/mL (663.94 mM)

Bioactivity

• In Vitro:
  TCN 213 (30 μM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NMDAR