TCN 213

SKU: orb1298924

Description

TCN 213 is a selective NMDA receptor antagonist with higher affinity for NR1/NR2A subunits over NR1/NR2B. This small molecule is a valuable research tool for studying synaptic plasticity, neuroprotection, and excitotoxicity in both cellular and animal models of neurological disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 556803-08-8
• MW: 376.54
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₂₄N₄OS₂
• SMILES: O=C(CSc1nnc(NCc2ccccc2)s1)NCC1CCCCC1
• Target: iGluR,NMDAR
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.31 mM);DMSO:30 mg/mL (79.67 mM)

Bioactivity

• Target IC50:
  GluN1/GluN2A NMDAR:0.55-40 μM (IC50)
• In Vitro:
  TCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions. Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope. TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible. In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity. In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents. Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NMDA receptor, monitor, neurones, Inhibitor, inhibit, Ionotropic glutamate receptors, glycine-dependentlly, iGluR, TCN 213, TCN213, TCN-213, surmountable, selective, pharmacologically

Compound Identifiers

PubChem CID

2608149