Talotrexin

SKU: orb1744445

Description

Talotrexin (PT523) is a nonpolyglutamatable antifolate analog that potently and selectively inhibits the Reduced Folate Carrier (RFC). Its primary mechanism involves targeting dihydrofolate reductase (DHFR), making it a valuable research tool for studying antifolate resistance and evaluating antitumor activity in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 113857-87-7
• MW: 573.56
• Formula: C₂₇H₂₇N₉O₆
• SMILES: NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCCNC(=O)C4=C(C(O)=O)C=CC=C4)C(O)=O)=O)C=C3)=N2)N=C(N)N1
• Target: Others,DHFR,Antifolate

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

130731