T863

SKU: orb1302657

Description

T-863 is a potent and selective oral DGAT1 inhibitor that binds the enzyme's acyl-CoA site to block cellular triacylglycerol synthesis. It has demonstrated efficacy in obese mouse models, reducing body weight, lowering hepatic and serum triglycerides, and improving insulin sensitivity, supporting its use in metabolic disease research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 701232-20-4
• MW: 394.47
• Purity: 99.88% (May vary between batches)
• Formula: C₂₂H₂₆N₄O₃
• SMILES: CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
• Target: Transferase,Acyltransferase
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.07 mM);DMSO:41.67 mg/mL (105.64 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, mono- acylglycerol acyltransferase, Diacylglycerol acyltransferase, DGAT3, DGAT-3, DGAT-1 inhibitor, DGAT1, DGAT 3, Diglyceride acyltransferase, acyl-CoA:cholesterol acyltransferase, Acyltransferase, T863, T-863, T 863

Compound Identifiers

PubChem CID

9865421