T863

SKU: orb1221862

Description

T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

Key Properties

• CAS Number: 701232-20-4
• MW: 394.47
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₆N₄O₃
• SMILES: O=C(O)C[C@@H]1CC[C@H](CC1)c2ccc(cc2)C4=Nc3c(ncnc3N)OC4(C)C
• Target: DNA/RNA Synthesis
• Solubility: DMSO : ≥ 50 mg/mL; 126.75 mM

Bioactivity

• In Vivo:
  Animal model: C57BL6 normal mice (8 weeks old) or diet-induced obese (DIO) mice (10 months old, fed a high fat diet for 8 months). Dosage: 30 mg/kg (5 μL/g). Administration: Oral administration; once a day for days 1-7 and twice a day for days 8-14. Result: Significantly delayed fat absorption and resulted in lipid accumulation in the distal small intestine of mice, mimicking the effects of genetic ablation of DGAT1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T863, T 863, T-863

Quick Database Links

Gene Symbol

DNA/RNA Synthesis