Suberoyl bis-hydroxamic acid

SKU: orb1306324

Description

Suberoyl bis-hydroxamic acid (SBHA) is a histone deacetylase (HDAC) inhibitor used in research to study epigenetic regulation. It is applied in both in vitro and in vivo models to investigate gene expression, cell cycle, differentiation, and potential therapeutic strategies in oncology and neurology.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 38937-66-5
• MW: 204.22
• Formula: C₈H₁₆N₂O₄
• SMILES: C(CCCCCCC(NO)=O)(NO)=O
• Target: Apoptosis|||HDAC
• Solubility: DMSO:49 mg/mL (239.94 mM);H2O:8.16 mg/mL (39.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.79 mM)

Bioactivity

• Target IC50:
  HDAC3:0.3 μm (JK cell)|HDAC1:0.25 μm (JK cell)
• In Vitro:
  In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

thyroid, SBHA, Suberoyl bis hydroxamic acid, Suberoyl bishydroxamic acid, Suberoyl bis-hydroxamic acid, Suberohydroxamic acid, Inhibitor, HDAC, HDAC3, HDAC1, Histone deacetylases, Malignant, Medullary, inhibit, MTC, neuroendocrine malignancy, mesothelioma, neoplastic disease, neoplasia, Apoptosis, carcinoma

Compound Identifiers

PubChem CID

5173