SBHA

SKU: orb1218077

Description

SBHA (suberohydroxamic acid) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.

Key Properties

• CAS Number: 38937-66-5
• MW: 204.22
• Purity: >98% (HPLC)
• Formula: C₈H₁₆N₂O₄
• SMILES: ONC(CCCCCCC(NO)=O)=O
• Target: HDAC
• Solubility: DMSO : 49 mg/mL (239.93 mM; Need ultrasonic); H2O : 8.16 mg/mL (40 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1(NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth. Animal model: Nude mice injected with human MTC cells. Dosage: 200 mg/kg. Administration: Intraperitoneal injection; every 2 days; 12 days. Result: Resulted in an average 55% inhibition of tumor growth in SBHA treatment group.
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• In Vitro:
  Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10-15% apoptosis), resulting in 45-50% cell death. Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL, which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells. Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells. Apoptosis Analysis Cell line: MM-BI and Ist-Mes2 cells. Concentration: 10 μM, 20 μM or 50 μM. Incubation time: 24 hours. Result: Showed a cooperative effect in cell apoptosis.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Suberohydroxamic acid | Suberoyl bis-hydroxamic acid

Quick Database Links

Gene Symbol

HDAC