SRI-37240

SKU: orb1688334

Description

SRI-37240

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 883956-47-6
• MW: 385.46
• Purity: 98.73%
• Formula: C₂₄H₂₃N₃O₂
• SMILES: O=C1C=2C=CC=CC2N(C=3N=C(C=4C=CC=CC4)N(C(=O)C13)C5CCCCC5)C
• Target: CFTR
• Solubility: DMSO:5 mg/mL (12.97 mM)

Bioactivity

• In Vitro:
  SRI-37240 (1, 3, 10, and 30 μM; 48 h) enhances CFTR-dependent chloride conductance in a concentration-dependent manner, activated by Forskolin and inhibited by CFTR Inh-172 . At 10 μM over 72 h, it significantly increases levels of both mature, fully glycosylated and immature CFTR protein forms in 16HBEge cells, especially when used with G418 (100 μM) . Additionally, at 10 μM for 24 h, SRI-37240 alters cellular translation termination at premature termination codons (PTCs) in HEK293T cells, boosts ribosome densities at normal stop codons, and does not affect ribosome densities in 3'-UTRs . The compound also restores CFTR function in primary bronchial epithelial cells with G418 treatment over 72 h . Western Blot Analysis shows a significant increase in both mature (Band C) and immature (Band B) CFTR protein forms at 10 μM for 24 h in CFTR-G542X 16HBEge cells with G418 (100 μM) .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CFTR

Compound Identifiers

PubChem CID

1856963