Sodium gualenate

SKU: orb1300057

Description

Sodium gualenate is a water-soluble derivative of guaiazulene with demonstrated anti-inflammatory and wound-healing properties. It is utilized in research models, including in vitro cellular assays and in vivo animal studies, to investigate mechanisms of inflammation and tissue repair.

Key Properties

• CAS Number: 6223-35-4
• MW: 300.35
• Purity: 99.70%
• Formula: C₁₅H₁₇NaO₃S
• SMILES: [Na+].CC(C)c1ccc(C)c2c(cc(C)c2c1)S([O-])(=O)=O
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.66 mM);DMSO:30 mg/mL (99.88 mM)

Bioactivity

• In Vivo:
  Sodium gualenate is frequently used to treat human gastritis, with its primary mechanism of action being the cytoprotection of the stomach's mucosal lining .
• Animal Research:
  The anti-gastric ulcer activity of compounds was tested through an ethanol-induced gastric ulcer mouse model method. Kunming mice, consisting of both males and females, each weighing about 25 g, were divided into groups of 8 at random. The tested compounds, Omeprazole and guaiazulene derivatives which were made into suspensions using 5% CMC-Na were administered orally (0.4 mL/20 g) to the dose group, the drug reference group and the GAS-Na group respectively. While the base control group was treated with only 5% CMC-Na. Vehicle or test compounds were administered by the oral route once a day for five consecutive days. After 0.5 h of the last dose, the mice were given orally 0.3 mL of anhydrous ethanol. Half an hour after anhydrous ethanol administration, the animals were killed. At last, the stomachs were removed and scored.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sodium gualenate, Guaiazulenesulfonate, Guaiazulenesulfonate sodium, inhibit, Inhibitor

Compound Identifiers

PubChem CID

23669592