SIRT5 inhibitor 7

SKU: orb1944441

Description

SIRT5 inhibitor 7 (compound 58) is a selective, substrate-competitive inhibitor (IC₅₀ = 310 nM). It has demonstrated efficacy in preclinical septic AKI models, reducing renal injury, modulating protein succinylation, and suppressing pro-inflammatory cytokine release in vivo. This inhibitor is a valuable tool for studying sirtuin biology and inflammation-related pathologies.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2951090-00-7
• MW: 582.12
• Purity: 99.77% (May vary between batches)
• Formula: C₂₈H₃₂ClN₇O₃S
• SMILES: N(CCCNC(NCCC(O)=O)=S)C=1C(C(=O)N2C[C@H](CC2)C3=CC=CC=C3)=CN=C(NC4=C(Cl)C=CC=C4)N1
• Target: Sirtuin

Bioactivity

• Target IC50:
  SIRT5:310 nM
• In Vivo:
  SIRT5 inhibitor 7 was tested in septic AKI mouse models induced by LPS and cecal ligation/perforation (CLP). SIRT5 inhibitor 7 significantly alleviated kidney dysfunction and histopathological injury, and reduced the release of proinflammatory cytokines in kidney tissue.
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• In Vitro:
  SIRT5 inhibitor 7 is a potent SIRT5 inhibitor with an IC₅₀ of 310 nM, acting as a substrate-competitive and selective inhibitor. In vitro, SIRT5 inhibitor 7 effectively inhibits SIRT5 enzymatic activity and modulates protein succinylation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168679824